Revisiting the putative TCR Cα dimerization model through structural analysis
نویسندگان
چکیده
منابع مشابه
Revisiting the putative TCR Cα dimerization model through structural analysis
Despite major advances in T cell receptor (TCR) biology and structure, how peptide-MHC complex (pMHC) ligands trigger αβ TCR activation remains unresolved. Two views exist. One model postulates that monomeric TCR-pMHC ligation events are sufficient while a second proposes that TCR-TCR dimerization in cis via Cα domain interaction plus pMHC binding is critical. We scrutinized 22 known TCR/pMHC c...
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Matthew Greaves is a Senior Lecturer in the Safety and Accident Investigation Centre at Cranfield University. Prior to joining Cranfield, he worked for the science and technology organization QinetiQ. He holds an engineering degree and a Ph.D. in aircraft engine noise and vibration. His research deals with the application of technology to the accident investigation process and he is an ESASI co...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2013
ISSN: 1664-3224
DOI: 10.3389/fimmu.2013.00016